Zou Tingting

  Professor

Email: zoutingting@mail.hzau.edu.cn

Tel: 027-87285221

Research Interest:

Bacterial antiphage systems

Phage lysis-lysogeny decisions

Education:

B. Sc. (2003)  Biotechnology  Wuhan University

Ph.D. (2008)  Microbiology   Wuhan University

Professional Experiences:

2009-2012  Post-doctoral Fellow  Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College

2012-2013   Assistant Professor   Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College

2013-2023 Associate Professor College of Life Science and Technology, Huazhong Agricultural University

2023-present  Professor College of Life Science and Technology, Huazhong Agricultural University

Selected Publications:

1. Wang Y^#, Guan Z^#, Wang C^#, Nie Y^#, Chen Y, Qian Z, Cui Y, Xu H, Wang Q, Zhao F, Zhang D, Tao P, Sun M, Yin P, Jin S, Wu S^*, Zou T^*. (2022) Cryo-EM structures of Escherichia coli Ec86 retron complexes reveal architecture and defence mechanism. Nature Microbiology. 7(9):1480-1489.

2. Cui Y^#, Su X^#, Wang C^#, Xu H, Hu D, Wang J, Pei K, Sun M, Zou T^*. (2022) Bacterial MazF/MazE toxin-antitoxin suppresses lytic propagation of arbitrium-containing phages. Cell Reports. Dec 6;41(10):111752.

3. Guan Z^#, Pei K ^#, Wang J, Cui Y, Zhu X, Su X, Zhou Y, Zhang D, Tang C, Yin P, Liu Z, Zou T^*（2019） Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage. Cell Discovery. 5:29.

4. Wang Q^#, Guan Z^#, Pei K, Wang J, Liu Z, Yin P, Peng D, Zou T^*（2018）Structural basis of the arbitrium peptide–AimR communication system in the phage lysis–lysogeny decision. Nature Microbiology. 3(11):1266-1273.

5. Yan L^#, Tang Q^#, Guan Z, Pei K, Zou T^*, He J^*（2018）Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. BBA General Subjects. 1862(9):1843-1851.

6. Chen Z^#, Bao L^#, Chen C^#, Zou T^#, Xue Y, Li F, Lv Q, Gu S, Gao X, Cui S, Wang J^*, Qin C^*, Jin Q^* (2017) Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset. J Infect Dis. 215(12):1807-1815.

7. Gao X^#, Zou T^#, Mu Z, Qin B, Yang J, Waltersperger S, Wang M, Cui S^*, Jin Q^*（2013）Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes. Nucleic Acids Res. 41(22):10529-411

8. Zou T^#, Yao X^#, Qin B, Zhang M, Cai L, Shang W, Svergun D I, Wang M^*, Cui S^*, Jin Q^* (2012) Crystal structure of Pseudomonas aeruginosa Tsi2 reveals a stably folded superhelical antitoxin. J Mol Biol. 417(4): 351-361.