张强 中共党员 博士、副教授、硕士生导师

研究方向

传染病致病与免疫机制；肠道微生物稳态与人体健康

教育经历

2005.9-2009.6  山东农业大学，动物医学，学士

2009.9-2015.6  华中农业大学，预防兽医学，博士

工作经历

2015.7-2020.9  华中农业大学，生命科学技术学院，博士后

2020.9至今 华中农业大学，副教授

发表论文

1. Zhang Q, Hu J, Feng J, Hu X, Wang T, Gong W, Huang K, Guo Y, Zou Z, Lin X, Zhou R, Yuan Y, Zhang A, Wei H, Cao G, Liu C*, Chen L*, Jin M*, Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020, 21(1):99.

2. Zhang Q#, Zhang H#, Gao J#, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z*, Shi Z*, Jin M*. A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect. 2020, 9(1):2013-2019.

3. Zhang Q#,  Huang J#, Yu J,  Xu Z,  Liu L, Song Y, Sun X, Zhang A* and Jin M*, HP1330 Contributes to Streptococcus suis Virulence by Inducing TLR2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads, Front Immunol. 2017, 8:869.

4. Huang K#, Zhang Q#, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*, Characterization of Spectinomycin Resistancein Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism, Antimicrob Agents Chemother. 2016, 7.25, (60): 6390~6392. (共同第一作者)

5. Zhang Q#, Yang Y#, Yan S, Liu J, Xu Z, Yu J, Song Y, Zhang A, Jin M*, A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway, Front Microbiol. 2015, 6: 178.

6. Zhang Q, Liu J, Yan S, Yang Y, Zhang A, Jin M*, Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts, J Clin Microbiol. 2013, 51(9):3130.

7. Zhang Q, Zhou M, Song D, Zhao J, Zhang A, Jin M*, Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China, Int J Antimicrob Ag, 2013, 42:87–89.

8. Zhou M#, Zhang Q#, Zhao J, Jin M*, Haemophilus parasuis Encodes Two Functional Cytolethal Distending Toxins: CdtC Contains an Atypical Cholesterol Recognition/Interaction Region, PLoS ONE, 2012, 7(3): e32580. (共同第一作者)

9. Liu L, Zhang Q, Xu Z, Chen B, Zhang A, Sun X, Jin M*. Screening of Virulence-Related Transcriptional Regulators in Streptococcus suis. Genes (Basel). 2020, 11(9): E972.

10. Li C, He X, Yang Y, Gong W, Huang K, Zhang Y, Yang Y, Sun X, Ren W, Zhang Q, Wu X*, Zou Z*, Jin M*. Rapid and visual detection of African swine fever virus antibody by using fluorescent immunochromatography test strip. Talanta. 2020, 219:121284.

11. Liu L, Zhang Q, Xu Z, Huang J, Zhu W, Zhang A, Sun X, Jin M*. HP1717 Contributes to Streptococcus suis Virulence by Inducing an Excessive Inflammatory Response and Influencing the Biosynthesis of the Capsule. Microorganisms, 2019, 7:11.

12. Zhu W, Cai C, Li J, Zhang Q, Huang J, Jin M*. Characterization of protective antigen CbpB as an adhesin and a plasminogen-binding protein of Erysipelothrix rhusiopathiae. Res Vet Sci. 2019, 124:352-356.

13. Xu Z, Chen B, Zhang Q, Liu L, Zhang A, Yang Y, Huang K, Yan S, Yu J, Sun X, Jin M*, Streptococcus suis 2 transcriptional regulator TstS stimulates cytokine production and bacteremia to promote streptococcal toxic shock-like syndrome, Front Microbiol, 2018, 9:1309.

14. Zhu W, Wu C, Kang C, Cai C, Wang Y, Li J, Zhang Q, Sun X, Jin M*. Evaluation of the protective efficacy of four newly identified surface proteins of Erysipelothrix rhusiopathiae. Vaccine. 2018, 36(52):8079-8083.

15. Zhu W, Zhang Q, Li J, Wei Y, Cai C, Liu L, Xu Z, Jin M*, Glyceraldehyde-3-phosphate dehydrogenase acts as an adhesin in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells and as a receptor in recruitment of host bronectin and plasminogen, Vet Res, 2017, 48:16.

16. Wang Y, Li J, Zhang A, Zhu W, Zhang Q, Xu Z, Yan S, Sun X, Chen H, Jin M*, iTRAQ-based quantitative proteomic analysis reveals potential virulence factors of Erysipelothrix rhusiopathiae, Journal of Proteomics, 2017, 160: 28–37.

17. Kang, C, Zhang Q, Zhu W, Cai C, Sun X, Jin M*, Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae, PLoS ONE, 2017, 12(10): e0185548.

18. Fu L, Zhao J, Lin L, Zhang Q, Xu Z, Han L, Xie C, Zhou R, Jin M, Zhang A*, Characterization of IgA1 protease as a surface protective antigen of Streptococcus suis serotype2, Microbes and Infection, 2016, 1.14, (18): 285~289.

19. Huang K, Yuan Z, Liu J, Zhang Q, Xu Z, Yan S, Zhang A, Jin M*. Identification and characterisation a surface-associated arginine peptidase in Streptococcus suis serotype 2. Microbiol Res. 2015, 170:168-176.

20. Wang N, Zou W, Yang Y, Guo X, Hua Y, Zhang Q, Zhao Z, Jin M*. Complete Genome Sequence of an H10N5 Avian Influenza Virus Isolated from Pigs in Central China, Journal of Virology, 2012, 86(24), pp 13865-13866.

授权专利

1. 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，表达副猪嗜血杆菌表面抗原的猪霍乱沙门氏菌减毒疫苗，2015.10.28，中国，ZL201310039113.8

2. 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，一种副猪嗜血杆菌减毒沙门氏菌苗，2015.10.28，中国，ZL201310039080.7

3. 金梅林，赵建平，周明光，宋岱松，张强，张安定，石建，康超，徐高原，陈焕春，一种副猪嗜血杆菌-猪霍乱沙门氏菌二联基因工程苗，2015.10.28，中国，ZL201310040712.1

主讲课程

《传染病学》、《实验诊断学》

基金项目

1. 国家自然科学基金青年科学基金项目，31702253，猪链球菌表面蛋白ZnMc诱导过度炎症反应的分子机制研究，2018/1-2020/12。

2. 中国博士后科学基金面上项目一等资助，2015M580654，猪链球菌2型抑炎蛋白HP1914作用机制的研究，2015/11-2017/11。

3. 国家重点研发计划，2016YFD0500801，家禽重大疫病诊断新技术研究， 2016/7-2020/12。

4. 国家重点研发计划，2020YFC0845800，新型冠状病毒感染不同进程与宿主的相互作用研究，2020/3-2021/6。

5. 湖北省新型肺炎应急科技攻关项目，2020FCA001，新型冠状病毒快速检测技术产品研发，2020/1-2020/12。

6. 湖北省技术创新专项重大项目，2019ABA089,非洲猪瘟防控关键技术研究与示范，2019/1-2021/12。