赖雪雷

博士 教授 博士生导师

教育经历（Education）

2013-2016: 荷兰格罗宁根大学（Bauke W. Dijkstra实验室） 生物化学与分子生物学 理学博士学位

2009-2012: 吉林大学 食品科学与工程专业 工学硕士学位

2005-2009: 长春工业大学 食品科学与工程专业 工学学士学位

2013-2016: University of Groningen (Bauke W. Dijkstra laboratory), Groningen, The Netherlands, PhD in Biochemistry and Molecular Biology

2009-2012: Jilin University, Changchun, Jilin, China, Master in Food Science and Technology

2005-2009: Changchun University of Technology, Changchun, Jilin, China, Bachelor in Food Science and Technology

科研与学术工作经历（Academic positions）

2021-现在: 作物遗传改良国家重点实验室 固定研究人员

2021-现在: 湖北洪山实验室 固定研究人员

2021-现在: 华中农业大学 生命科学技术学院 教授

2017-2021: 法国国家科学院（Francois Parcy和Chloe Zubieta实验室） 博士后

2016-2017: 英国剑桥大学（Philip A. Wigge实验室） 博士后

2021-Present: Principal Investigator, National Key Laboratory of Crop Genetic Improvement, Wuhan, China

2021-Present: Principal Investigator, Hubei Hongshan Laboratory, Wuhan, China

2021-Present: Full Professor, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China  

2017-2021: Postdoc, The French National Centre for Scientific Research (Francois Parcy and Chloe Zubieta laboratory), Grenoble, France

2016-2017: Postdoc, The Sainsbury Laboratory, University of Cambridge (Philip A. Wigge), Cambridge, UK

研究方向（Research topics）

实验室主要以拟南芥和水稻为模型，采用分子生物学、生物化学、结构生物学、基因组学和生物信息学等手段，研究植（作）物温度感应机制（包括温度感知、信号传导和温度响应），并探索作物应对气候变化的遗传改良策略。

We use Arabidopsis thaliana and rice (Oryza sativa) as model systems, and apply integrated approaches of molecular biology, biochemistry, structural biology, genomics and bioinformatics to study plant temperature sensing mechanisms, answering key questions of how plants perceive temperature, how temperature signal was transmitted and how plants respond to temperature changes. Our ultimate goal is to breed climate-resilient crop varieties for the ever-increasing world population in the context of global climate change.

实验室招聘（Come and join us）

实验室依托作物遗传改良国家重点实验室和湖北洪山实验室的优势实验平台，现招收博士后2-3名、博士研究生1-2名/年和硕士研究生2-4名/年。欢迎对“气候变化”、“温度感应”、“作物遗传改良”和“转录因子-顺势作用原件互作”等关键词感兴趣的有志之士加入。

We are part of the National Key Laboratory of Crop Genetic Improvement and the newly established Hubei Hongshan Laboratory, which are both among the most advanced and promising plant and crop research centers in China. Our lab is recruiting postdoc researchers (2-3), PhD students (1-2 per year) and master students (2-4 per year). We welcome motivated researchers and students who are interested in key words, e.g., climate change, temperature sensing, crop genetic improvement, transcription factor and cis-element interaction, to join us. We provide competitive salary, housing and state-of-the-art research facilities.

代表性研究成果（*共一; #通讯作者）（Representative papers）

Lai, X.*, Vega-Leon, R.*, Hugouvieux, V.*#, Blanc-Mathieu, R. van der Wal, F., Lucas, J., Silva, C.S., Jourdain, A., Muino, J., Nanao, M.H., Immink, R., Kaufmann, K., Parcy, F., Smaczniak, C.#, Zubieta C.# (2021). The Intervening Domain Is Required For DNA-binding and Functional Identity of Plant MADS Transcription Factors. Nat. Commun. 12 (4760).

Lai, X.*, Blanc-Mathieu, R.*, GrandVuillemin L., Huang, Y., Stigliani, A., Lucas, J., Thévenon, E., Loue-Manifel, J., Turchi, L., Daher, H., Brun-Hernandez, E., Vachon, G., Latrasse, D., Benhamed, M., Dumas, R., Zubieta, C., and Parcy, F.# (2021). The LEAFY floral regulator displays pioneer transcription factor properties. Mol. Plant 14(5):829-837.

Lai, X.*, Stigliani, A.*, Lucas, J., Hugouvieux, V., Parcy, F.#, and Zubieta, C.# (2020). Genome-wide binding of SEPALLATA3 and AGAMOUS complexes determined by sequential DNA-affinity purification sequencing. Nucleic Acids Res. 48 (17), 9637–9648.

Silva, C.S.*#, Nayak, A.*, Lai, X.*, Hutin, S.#, Hugouvieux, V., Jung, J.-H., López-Vidriero, I., Franco-Zorrilla, J.M., Panigrahi, K.C.S., Nanao, M.H., Wigge, P.A., and Zubieta, C.,# (2020). Molecular mechanisms of Evening Complex activity in Arabidopsis. Proc. Natl. Acad. Sci. USA 117 (12), 6901–6909.

Lai, X.*, Chahtane, H.*, Martin-Arevalillo, R., Zubieta, C., and Parcy, F.# (2020). Contrasted evolutionary trajectories of plant transcription factors. Curr. Opin. Plant Biol. 54, 101–107.

Lai, X.#, Stigliani, A., Vachon, G., Carles, C., Smaczniak, C., Zubieta, C., Kaufmann, K., and Parcy, F.# (2019). Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants. Mol. Plant 12 (6), 743–763.

Lai, X., Wichers, H.J., Soler‐Lopez, M.#, and Dijkstra, B.W.# (2017). Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew. Chem. Int. Ed. 56 (33), 9812–9815.

获得奖励（Awards）

2017年国家优秀自费留学生奖学金

欧洲同步辐射光源博士学位全额奖学金（2013-2016年）

2017 The Chinese Government Award for Outstanding Students Abroad

2013-2016 Full PhD scholarship of European Synchrotron Radiation Facility

主讲课程（Teaching）

生物化学（Biochemistry）、分子生物学 （Molecular Biology）

研究生招生专业（Subjects for graduate students）

生物化学（Biochemistry）、分子生物学（Molecular Biology）、结构生物学（Structural Biology）、基因组学 （Genomics）

联系方式

电子邮箱：xuelei_lai@mail.hzau.edu.cn

办公地点：作物遗传改良国家重点实验室（第二综合楼）B612（水稻温度感应实验室）

Contacts:

Email: xuelei_lai@mail.hzau.edu.cn

Twitter: https://twitter.com/Xuelei_Lai

Google scholar: https://scholar.google.co.uk/citations?user=3NaY5wUAAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Xu

Address:

B612, Rice temperature sensing group,

National Key Laboratory of Crop Genetic Improvement,

Hubei Hongshan Laboratory, Huazhong Agricultural University,

No.1, Shizishan Street, Hongshan District, Wuhan, Hubei Province, P.R.China