何璟 　博士 　教授 　博士生导师 　中国微生物学会普通微生物学专业委员会委员

教育经历

1995-1999 华中农业大学 生命科学技术学院 生物技术专业 理学学士学位

1998-2001华中农业大学 生命科学技术学院 生物化学与分子生物学专业 理学硕士学位

2001-2005　Friedrich-Schiller-Universität Jena（德国耶拿大学） Hans-Knoll-Institute for Natural Products Research（天然产物研究所）理学博士学位

科研与学术工作经历

2005-2007　Rheinische Friedrich-Wilhelms-Universität Bonn（德国波恩大学）Kekulé Institute of Organic Chemistry and Biochemistry（有机化学和生物化学研究所） 博士后

2007-2008　University of Chicago（美国芝加哥大学） Department of Chemistry（化学系）博士后

2008-至今 华中农业大学 生命科学技术学院 教授

研究方向

主要研究链霉菌次级代谢合成、调控及抗性机制

代表性研究成果

论文

1. Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*. Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. Biochem Biophys Res Commun. 2016, 473(1):329-335. DOI:10.1016/j.bbrc.2016.03.105 (SCI收录, IF 2.371) DOI:10.1016/j.bbrc.2016.03.105

2. Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*. Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage. Nucleic Acids Res. 2016, 44(1):187-197. (SCI收录, 9.202) DOI:10.1093/nar/gkv949

3. Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li*. Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain. PLos One. 2015, 10(2):e0117690. (SCI收录, IF 3.234) DOI:10.1371/journal.pone.0117690　

4. Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck. Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl. 2013, 52(20):5285-5289. (SCI收录, IF 12.525) DOI:10.1002/anie.201301322

5. Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*. Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi. FEMS Microbiol Lett. 2012, 337(2):147-154. (SCI收录, IF 2.295) DOI:10.1111/1574-6968.12020

6. Sheng Huang, Yudong Zhao,Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*. Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry. 2011, 46(3):811-816. (SCI收录, IF 3.225)

7. Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc. 2010, 132(30):10407-10413. (SCI收录, IF 9.545) DOI:10.1021/ja102751h

8. Keya Zhang, Jing He, Min Yang, Jun Yin. Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection. Chembiochem. 2009, 10(16):2599-2606. (SCI收录, IF 3.853) DOI:10.1002/cbic.200900297

9. Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem. 2007, 8(15):1841-1849. (SCI收录, IF 3.94) DOI:10.1002/cbic.200700309

10. Markus Muller, Jing He, Christian Hertweck. Dissection of the late steps in aureothin biosynthesis. Chembiochem. 2006, 7(1):37-39. (SCI收录, IF 3.94) DOI:10.1002/cbic.200500161

11. Jing He and Christian Hertweck. Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase. ChembioChem. 2005, 6(5):908-912. (SCI收录, IF 3.94) DOI:10.1002/cbic.200400333

12. Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck. Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect. Angewandte Chemie, Chem. Int. Ed. Engl. 2005, 44(8):1202-1205. (SCI收录, IF 9.596) DOI:10.1002/anie.200461990

13. Jing He, Markus Müller and Christian Hertweck. Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase. J. Am. Chem. Soc. 2004, 126(51):16742-16743. (SCI收录, IF 6.903) DOI:10.1021/ja046104h

14. Jing He and Christian Hertweck. Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase. J. Am. Chem. Soc. 2004, 126(12):3694-3695. (SCI收录, IF 6.903) DOI:10.1021/ja039328t

15. Jing He and Christian Hertweck. Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster. Chem. Biol. 2003, 10(12):1225-1232. (SCI收录, IF 6.129)

16. Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng. Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex. Chem. Biol. 2003, 10(11):1065-1076. (SCI收录, IF 6.129)

授权专利

1. 何璟，王珊，一种阿嗪霉素B的基因工程菌WSD2CP及制备方法和应用，2013，中国，专利号ZL 201210110348.7。

2. 何璟，朱梦奕，赵瑞芳，王利娟，硫藤黄链霉菌抗生素调控基因及提高链霉菌抗生素产量的方法，2013，中国，专利号ZL 201310177365.7。

3. Christian Hertweck，Jing He，“Amino-Oxidase” from Streptomyces thioluteus. 2003，欧洲，专利号10335447.6。

4. Christian Hertweck, Martina Ziehl, Jing He, H.-M. Dahse，“HKI 10429005, neue zytostatische Wirkstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung” . 2004，欧洲，专利号102004040014.8

获得奖励

2009年入选教育部新世纪优秀人才支持计划

2004年获国家优秀自费留学生奖学金，

主讲课程

微生物遗传育种，化学生物学

研究生招生专业

微生物学

联系方式

联系电话：15072356673

电子邮箱：hejingjj@mail.hzau.edu.cn

办公地点：农业微生物学国家重点实验室A座604室

实验室介绍及网址：

http://ibi.hzau.edu.cn/clstest/researchers.php?id=174