遗传及细胞生物学教研室Brief Introduction

张敏
时间:2016-09-20

 

 

张敏 博士  教授  

教育经历

1998-2002  华中农业大学水产学院 淡水渔业 理学学士学位

2003-2008  中科院水生生物研究所  水生生物学  理学博士学位

 

科研与学术工作经历

2015-至今   华中农业大学 生命科学技术学院        教授

2009-2015   加州大学戴维斯分校 兽医学院         博士后

2008-2009   中科院水生生物研究所  蛋白质工程      助理研究员

                   

 

研究方向

RNA结合蛋白在器官发育与癌症发生中作用与机制

 

代表性研究成果

论文1

1.     Zhang, M., Zhang, J., Yan, W. & Chen, X. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget 7, 78255-78268, doi:10.18632/oncotarget.13126 (2016).

2.     Zhang, M., Xu, E., Zhang, J. & Chen, X. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene 34, 5900-5911, doi:10.1038/onc.2015.31 (2015).

3.     Zhang, M., Zhang, J., Chen, XL., Cho, SJ., Chen, XB. (2013) Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes & Development 27(20): 2246-2258.

4.     Zhang, M., Zhang, C., Li, J., Hanna, M., Zhang, X., Dai, H. and Xiao, W. (2011) Inactivation of YAP1 enhances sensitivity of the yeast RNR3-lacZ genotoxicity testing system to a broad range of DNA-damaging agents. Tox. Sci. 120: 310-321. 

5.     Zhang, M., Hanna, M., Li, J., Butcher, S., Dai, H. and Xiao, W. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Tox. Sci. 113: 401-411.

6.     Zhang, M., Liang, Y., Zhang, X., Xu, Y., Dai, H. and Xiao, W. (2008) Deletion of yeast CWP genes enhances cell permeability to genotoxic agents. Toxicol. Sci. 103: 68-76. 

7.     Zhang, J., Xu, EX., Cong, R., Yang,WS., Zhang, M., Chen, MY., Cardiffd, R., Imaie D., Wisnerb, E., Chen XB. (2014) Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A 111(52): 18637-18642. 

8.     Jiang, Y. Q., Zhang, M; Qian, Yingjuan; et al (2014) Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability. Journal of Biological Chemistry 289(6): 3164-3175. 

9.     Xu, Enshun; Zhang, Jin; Zhang, Min; et al. (2014) RNA-Binding Protein RBM24 Regulates p63 Expression via mRNA Stability. Molecular Cancer Research 12(3): 359-369. 

10.   Cho, SJ., Rossi, A., Jung, YS., Yan, WS., Liu, G., Zhang, J.,Zhang, M., Chen, XB. (2013) Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proceedings of the National Academy of Sciences of the United States of America 110(23): 9362-9367.

11.   Chen, X. L., Zhang, J., Zhang, M., Liu, S., Yan, WS., Jung, JH., Chen, XB. (2012) Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-independent Proteasomal Degradation. Journal of Biological Chemistry 287(41): 34410-34418. 

12.   Dai, H., Zhang, M., Zhang, C., Wei, T., Xu, Y., and Xiao, W. 2011Developing sensitive assessment system for environmental chemical carcinogens detection Curr. Opin. Biotechnol. 22, Supplement 1, S71.

13.   Wang, Y., Zhang, X., Xiao, N. Zhang, M., Dai, H. Selection of a novel single-chain variable fragment antibody specifically against a linear epitope of white spot syndrome virus. Sheng Wu Gong Cheng Xue Bao, 2008, 24(8): 1387-94.

14.   杨毅;张敏;袁丽;张晓华;戴和平;.抗对虾白斑综合症病毒单链抗体P1D3基因在毕赤酵母中的分泌表达,生物工程学报,2006,22(6):973-978

授权专利

所有专利权人,专利名称,授权日期,中国(美国),专利号ZL201210137450.6

戴和平, 肖伟张敏, 张晓华, 可用于检测环境致癌物的高通透性面包酵母及其制备方法20080813 中国  CN101240251A

戴和平, 肖伟张敏, 张晓华, 一种超高通透性面包酵母及其制备方法 20110713 中国 CN200910272505.2

戴和平, 肖伟,张超,张敏, 张晓华,一种对氧化损伤高敏感性的面包酵母及其制备方法 20130619 中国CN102120968A

其他成果

 

获得奖励

 

主讲课程

发育生物学

 

研究生招生专业

发育生物学

 

联系方式

实验室电话:

电子邮箱:minzhang@mail.hzau.edu.cn

办公地点:基因楼414

 

实验室介绍及网址:

中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 Fax:+86-27-87282469
CopyRight©2001-2010 华中农业大学生命科学技术学院 版权所有; E-mail:bio@mail.hzau.edu.cn 技术支持:现代教育技术中心