微生物学教研室Brief Introduction

何璟
时间:2015-11-05

何璟  博士  教授  博士生导师  中国微生物学会普通微生物学专业委员会委员

教育经历

1995-1999 华中农业大学 生命科学技术学院 生物技术专业 理学学士学位

1998-2001华中农业大学 生命科学技术学院 生物化学与分子生物学专业 理学硕士学位

2001-2005 Friedrich-Schiller-Universität Jena德国耶拿大学 Hans-Knoll-Institute for Natural Products Research天然产物研究所理学博士学位

科研与学术工作经历

2005-2007 Rheinische Friedrich-Wilhelms-Universität Bonn德国波恩大学Kekulé Institute of Organic Chemistry and Biochemistry有机化学和生物化学研究所博士后

2007-2008 University of Chicago国芝加哥大学 Department of Chemistry(化学系)博士后

2008-至今 华中农业大学 生命科学技术学院 教授

 

研究方向

主要研究链霉菌次级代谢合成、调控及抗性机制

 

代表性研究成果

论文

1. Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*. Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. Biochem Biophys Res Commun. 2016, 473(1):329-335. DOI:10.1016/j.bbrc.2016.03.105 (SCI收录, IF 2.371) DOI:10.1016/j.bbrc.2016.03.105

2. Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*. Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage. Nucleic Acids Res. 2016, 44(1):187-197. (SCI收录, 9.202) DOI:10.1093/nar/gkv949 

3. Jin Lu, Qiang He, Luyao Huang, Xiaofeng Cai, Wenwen Guo, Jing He, Lili Zhang, Aiying Li*. Accumulation of a bioactive benzoisochromanequinone compound kalafungin by wild type antitumor-medermycin-producing streptomycete strain. PLos One. 2015, 10(2):e0117690. (SCI收录, IF 3.234) DOI:10.1371/journal.pone.0117690 

4. Benjamin Busch, Nico Ueberschaar, Swantje Behnken, Yuki Sugimoto, Martina Werneburg, Nelly Traitcheva, Jing He, Christian Hertweck. Multifactorial control of iteration events in a modular polyketide assembly line. Angew Chem Int Ed Engl. 2013, 52(20):5285-5289. (SCI收录, IF 12.525) DOI:10.1002/anie.201301322

5. Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*. Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi. FEMS Microbiol Lett. 2012, 337(2):147-154. (SCI收录, IF 2.295) DOI:10.1111/1574-6968.12020

6. Sheng Huang, Yudong Zhao,Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*. Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry. 2011, 46(3):811-816. (SCI收录, IF 3.225)

7. Martina Werneburg, Benjamin Busch, Jing He, Martin E.A. Richter, Longkuan Xiang, Bradley S. Moore, Martin Roth, Hans-Martin Dahse, Christian Hertweck. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues. J Am Chem Soc. 2010, 132(30):10407-10413. (SCI收录, IF 9.545) DOI:10.1021/ja102751h

8. Keya Zhang, Jing He, Min Yang, Jun Yin. Identifying natural product biosynthetic genes from a soil metagenome by using T7 phage selection. Chembiochem. 2009, 10(16):2599-2606. (SCI收录, IF 3.853) DOI:10.1002/cbic.200900297

9. Nelly Traitcheva, Holger Jenke-Kodama, Jing He, Elke Dittmann and Christian Hertweck. Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways: an evolutionary perspective. Chembiochem. 2007, 8(15):1841-1849. (SCI收录, IF 3.94) DOI:10.1002/cbic.200700309

10. Markus Muller, Jing He, Christian Hertweck. Dissection of the late steps in aureothin biosynthesis. Chembiochem. 2006, 7(1):37-39. (SCI收录, IF 3.94) DOI:10.1002/cbic.200500161

11. Jing He and Christian Hertweck. Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase. ChembioChem. 2005, 6(5):908-912. (SCI收录, IF 3.94) DOI:10.1002/cbic.200400333

12. Martina Ziehl, Jing He, H.-M. Dahse and Christian Hertweck. Mutasynthesis of Aureonitrile, an Aureothin Derivative with Significant Cytostatic Effect. Angewandte Chemie, Chem. Int. Ed. Engl. 2005, 44(8):1202-1205. (SCI收录, IF 9.596) DOI:10.1002/anie.200461990

13. Jing He, Markus Müller and Christian Hertweck. Formation of the Aureothin Tetrahydrofuran Ring by a Bifunctional Cytochrome P450 Monooxygenase. J. Am. Chem. Soc. 2004, 126(51):16742-16743. (SCI收录, IF 6.903) DOI:10.1021/ja046104h

14. Jing He and Christian Hertweck. Biosynthetic Origin of the Rare Nitro Aryl Moiety of the Polyketide Antibiotic Aureothin: Discovery of an Unprecedented N-Oxygenase. J. Am. Chem. Soc. 2004, 126(12):3694-3695. (SCI收录, IF 6.903) DOI:10.1021/ja039328t

15. Jing He and Christian Hertweck. Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster. Chem. Biol. 2003, 10(12):1225-1232. (SCI收录, IF 6.129)

16. Shi Chen, Xi Huang, Xiufen Zhou, Linquan Bai, Jing He, Ki Jun Jeong, Sang Yup Lee, and Zixin Deng. Organizational and Mutational Analysis of a Complete FR-008/ Candicidin Gene Cluster Encoding a Structurally Related Polyene Complex. Chem. Biol. 2003, 10(11):1065-1076. (SCI收录, IF 6.129)

 

授权专利

1. 何璟王珊一种阿嗪霉素B的基因工程菌WSD2CP及制备方法和应用,2013,中国专利号ZL 201210110348.7

2. 何璟,朱梦奕,赵瑞芳,王利娟硫藤黄链霉菌抗生素调控基因及提高链霉菌抗生素产量的方法,2013,中国,专利号ZL 201310177365.7

3. Christian HertweckJing He“Amino-Oxidase” from Streptomyces thioluteus. 2003欧洲,专利号10335447.6

4. Christian Hertweck, Martina Ziehl, Jing He, H.-M. Dahse“HKI 10429005, neue zytostatische Wirkstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung” . 2004欧洲,专利号102004040014.8

 

获得奖励

2009年入选教育部新世纪优秀人才支持计划

2004年获国家优秀自费留学生奖学金,

 

主讲课程

微生物遗传育种,化学生物学

 

研究生招生专业

微生物学

 

联系方式

联系电话:15072356673

电子邮箱:hejingjj@mail.hzau.edu.cn

办公地点:农业微生物学国家重点实验室A604

 

实验室介绍及网址:

http://ibi.hzau.edu.cn/clstest/researchers.php?id=174

中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 Fax:+86-27-87282469
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