微生物工程教研室Brief Introduction

何进
时间:2015-11-03

 

 

何进  博士  教授  博士生导师

教育经历

1985-1989 华中农业大学土化系土壤农化专业学士学位

1991-1994 华中农业大学食品科技系食品科学专业硕士学位

1999-2003 华中农业大学生命科学技术学院微生物学专业博士学位

 

科研与学术工作经历

1989-1991 武汉双凤柠檬酸有限公司技术员

1994-至今华中农业大学生命科学技术学院讲师、副教授、教授

2006-2008 伊利诺伊大学香槟分校微生物学系博士后

 

研究方向

微生物代谢工程,微生物功能基因组学,芽胞杆菌及分枝杆菌的代谢调控、细菌核苷类第二信使分子及非编码RNA的功能等。

 

代表性研究成果(近五年)

近期主要论文

[1]    Maria Kanwal Ali, Xinfeng Li, Qing Tang, Xiaoyu Liu, Fang Chen, Jinfeng Xiao, Muhammad Ali, Shan-Ho Chou, Jin He*. Regulation of inducible potassium transporter KdpFABC by KdpD/KdpE two-component system in Mycobacterium smegmatis. Frontiers in Microbiology, 2017, 8: 570. doi: 10.3389/fmicb.2017.00570.

[2]    Jianmei Su, Zhou Li, Bei Liao, Chunhong Wang, Jin He*. Microcalorimetric study of the effect of manganese on the growth and metabolism in a heterogeneously expressing manganese-dependent superoxide dismutase (Mn-SOD) strain. Journal of Thermal Analysis and Calorimetry, 2017, doi: 10.1007/s10973-017-6282-8.

[3]    Qing Tang, Kang Yin, Hongliang Qian, Youwen Zhao, Wen Wang, Shan-Ho Chou, Yang Fu, Jin He*. Cyclic di-GMP contributes to adaption and virulence of Bacillus thuringiensis through a riboswitch-regulated collagen adhesion protein. Scientific Reports, 2016, 6: 28807. doi: 10.1038/srep28807.

[4]    Xun Wang, Zhou Li, Xin Li, Hongliang Qian, Xia Cai, Xinfeng Li, Jin He*. Poly-β-hydroxybutyrate metabolism is unrelated to the sporulation and parasporal crystal protein formation in Bacillus thuringiensis. Frontiers in Microbiology, 2016, 7: 836. doi: 10.3389/fmicb.2016.00836.

[5]    Shumeng Zhang, Xinfeng Li, Xun Wang, Zhou Li, Jin He*. The two-component signal transduction system YvcPQ regulates the bacterial resistance to bacitracin in Bacillus thuringiensis. Archives of Microbiology, 2016, 198(8): 773-784. doi: 10.1007/s00203-016-1239-z

[6]    Jianmei Su, Xia Zou, Liangbo Huang, Tenglong Bai, Shu Liu, Meng Yuan, Shan-Ho Chou, Ya-Wen He, Haihong Wang, Jin He*. DgcA, a diguanylate cyclase from Xanthomonas oryzae pv. oryzae regulates bacterial pathogenicity on rice. Scientific Reports, 2016, 6: 25978. doi: 10.1038/srep25978.

[7]    Hang Zhou#, Cao Zheng#, Jianmei Su#, Bo Chen, Yang Fu, Yuqun Xie, Qing Tang, Shan-Ho Chou, Jin He*. Characterization of a natural triple-tandem c-di-GMP riboswitch and application of the riboswitch-based dual-fluorescence reporter. Scientific Reports, 2016, 6: 20871. doi: 10.1038/srep20871.

[8]    Han Mei, Qing Tang, Xinfeng Li, Yaxi Wang, Jieping Wang, Jin He*. Insights into sRNA genes regulated by two-component systems in the Bacillus cereus group. Current Bioinformatics, 2015, 10(4): 456-468. doi: 10.2174/157489361004150922151028. 

[9]    Cao Zheng, Yang Ma, Xun Wang, Yuqun Xie, Maria Kanwal Ali, Jin He*. Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis. Frontiers in Microbiology, 2015, 6: 908. doi: 10.3389/fmicb.2015.00908.

[10]  Shumeng Zhang, Yimin Hu, Qingyun Fan, Xun Wang, Jin He*. Two-component system YvqEC-dependent bacterial resistance against vancomycin in Bacillus thuringiensis. Antonie van Leeuwenhoek, 2015, 108(2): 365-376.doi: 10.1007/s10482-015-0489-0.

[11]  Qing Tang, Yunchao Luo, Cao Zheng, Kang Yin, Maria Kanwal Ali, Xinfeng Li, Jin He*. Functional analysis of a c-di-AMP-specific phosphodiesterase MsPDE from Mycobacterium smegmatisInternational Journal of Biological Sciences, 2015, 11(7): 813-824. doi: 10.7150/ijbs.11797.

[12]  Qing Tang, Xinfeng Li, Tingting Zou, Huimin Zhang, Yingying Wang, Rongsui Gao, Zhencui Li, Jin He*, Youjun Feng*. Mycobacteria smegmatis BioQ defines a new regulatory network for biotin metabolism. Molecular Microbiology, 2014, 94 (5): 1006-1023. doi: 10.1111/mmi.12817.

[13]  Bei Liao#, Yaxi Wang#, Jianmei Su, Fan Liu and Jin He*. Expression of Vitreoscilla hemoglobin in Bacillus thuringiensis can promote manganese oxidation under oxygen-restricted condition. Annals of Microbiology, 2014, 64 (4): 1865-1868. doi: 10.1007/s13213-014-0825-z.

[14]  Shumeng Zhang, Jieping Wang, Yale Wei, Qing Tang, Maria Kanwal Ali, Jin He* Heterologous expression of VHb can improve the yield and quality of biocontrol fungus Paecilomyces lilacinus, during submerged fermentation. Journal of Biotechnology, 2014, 187, 147-153. doi: 10.1016/j.jbiotec.2014.07.438.

[15]  Jianmei Su, Lin Deng, Liangbo Huang, Shujin Guo, Fan Liu and Jin He*. Catalytic oxidation of manganese(II) by multicopper oxidase CueO and characterization of the biogenic Mn oxide. Water Research, 2014, 56, 304-313. doi: 10.1016/j.watres.2014.03.013.

[16]  Jieping Wang#, Han Mei#, Hongliang Qian, Qing Tang, Xiaocui Liu, Ziniu Yu, Jin He*. Expression profile and regulation of spore and parasporal crystal formation-associated genes in Bacillus thuringiensis. Journal of Proteome Research, 2013, 12(12): 5487-5501.

[17]  Jieping Wang#, Xulu Ai#, Han Mei#, Yang Fu, Bo Chen, Ziniu Yu, Jin He*. High-throughput identification of promoters and screening of highly active promoter-5’-UTR DNA region with different characteristics from Bacillus thuringiensis. PLoS ONE, 2013, 8(5): e62960. doi: 10.1371/journal.pone.0062960.

[18]  Jieping Wang, Han Mei, Cao Zheng, Hongliang Qian, Cui Cui, Yang Fu, Jianmei Su, Ziduo Liu, Ziniu Yu, Jin He*. The metabolic regulation of Bacillus thuringiensis for the formation of spores and parasporal crystals revealed by the transcriptomics and proteomics. Molecular and Cellular Proteomics, 2013, 12(5): 1363-1376. doi: 10.1074/mcp.M112.023986.

[19]  Cao Zheng, Jieping Wang, Yunchao Luo, Yang Fu, Jianmei Su, Jin He*. Highly efficient enzymatic preparation of c-di-AMP using the diadenylate cyclase DisA from Bacillus thuringiensis. Enzyme and Microbial Technology, 2013, 52(6-7): 319-324. doi: 10.1016/j.enzmictec.2013.03.007.

[20]  Jianmei Su, Peng Bao, Tenglong Bai, Lin Deng, Hui Wu, Fan Liu, Jin He*. CotA, a muticopper oxidase from Bacillus pumilus WH4, exhibits manganese-oxidase activity. PLoS ONE, 2013, 8(4): e60573. doi: 10.1371/journal.pone.0060573.

 

授权专利

所有专利权人,专利名称,授权日期,中国(美国),专利号ZL201210137450.6

Ø 何进、危雅乐、王阶平、张艳、郝勃,重组淡紫拟青霉菌株PNVT8及其应用,20151021,中国,专利号ZL201310406991.9

 

其他成果

Ø 《理工复合协同育人培养高素质生物工程专业人才》,华中农业大学教学成果一等奖(排名第三),2016.12

 

获得奖励

Ø 2015-2016年度华中农业大学优秀博士学位论文指导教师,20172

Ø 2015年度华中农业大学研究生教书育人奖,20161

Ø 湖北省优秀硕士学位论文指导教师,201212

Ø 华中农业大学优秀硕士学位论文指导教师,201212月,201012

Ø 湖北省优秀学士学位论文指导教师,2013届、2014届、2015届、2016

Ø 华中农业大学本科生毕业论文(设计)创新奖指导教师, 2012届、2013届、2014届、2015届、2016

Ø 2008年校级优质课程《生物工程综合大实验》(华中农业大学,主要参与,排名第二)

Ø 武汉市科技进步二等奖,200512

Ø 2005年度华中农业大学教学质量优秀三等奖

Ø 2005年度湖北省大学生优秀科研成果奖一等奖指导教师(指导2人同时获省一等奖)

Ø 湖北省优秀博士学位论文奖,200412

Ø 2004年度湖北省大学生优秀科研成果奖二等奖指导教师

Ø 2004年度国家精品课程《微生物学》(主要参与,排名第五)

 

主讲课程

普通微生物学、生物分离工程、生物工程综合实验四

 

研究生招生专业

微生物学生物工程

学术兼职

Current Bioinformatics》、《微生物学杂志》、《生物资源》编委;生物工程专业负责人

 

联系方式

实验室电话:

电子邮箱hejin@mail.hzau.edu.cn

办公地点:第一综合楼A401、农业微生物学国家重点实验室A311

 

实验室介绍及网址:

建设中……

中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 Fax:+86-27-87282469
CopyRight©2001-2010 华中农业大学生命科学技术学院 版权所有; E-mail:bio@mail.hzau.edu.cn 技术支持:现代教育技术中心