微生物工程教研室Brief Introduction

祁高富
时间:2015-11-05

 

教育经历

  2001/9 - 2004/7,中国药科大学生命科学与技术学院微生物与生化药学博士,导师:刘景晶

  1995/9 - 1998/7,南京林业大学,森林资源与环境学院森林保护系,硕士,导师:叶建仁

   1991/9 - 1995/7,南京林业大学林学院,学士

 

科研与学术工作经历

2009/03 - 至今,华中农业大学,生命科学技术学院,副教授

2008/03-2009/03,英国伦敦血栓研究所(Thrombosis Research Institute),博士后,合作导师:Xinjie Lu

2006/12-2007/12加拿大DALHOUSIE大学医学院,微生物感染与免疫系,博士后,合作导师:Song Lee, Jun Wang

2004/08-2006/12华中农业大学,生命科学技术学院,讲师

 

研究方向

微生物代谢:群体感应信号分子与代谢

微生物药物:从微生物代谢物中寻找活性分子,用于胰岛素的口服给药

微生物与免疫:微生物代谢物的免疫活性研究与抗肿瘤疫苗

 

代表性研究成果 

(1) Wang R, Zhang H, Sun L, Qi G, Chen S, Zhao X, Microbial community composition is related to soil biological and chemical properties and bacterial wilt outbreak, Sci Rep, 2017, 7(1):343.

(2) Zhang L, Xing X, Ding J, Zhao X, Qi G*, Surfactin variants for intra-intestinal delivery of insulin. Eur J Pharm Biopharm, 2017, 17: 30141-8.

(3) Zhang H, Wang R, Chen S, Qi G, He Z, Zhao X, Microbial taxa and functional genes shift in degraded soil with bacterial wilt, Sci Rep 2017, 7:39911.

(4) Gan P, Gao Z, Zhao X, Qi G*, Surfactin inducing mitochondria-dependent ROS to activate MAPKs, NF-κB and inflammasomes in macrophages for adjuvant activity, Sci Rep 2016, 6:39303.

(5) Zhao H, Zhao X, Du P, Qi G*, Construction of random tumor transcriptome expression library for creating and selecting novel tumor antigens, Tumor Biology, 2016, 37(9):12877-12887. 

(6) Bie N, Zhao X, Li Z, Qi G*, Constructing Tumor Vaccines Targeting for Vascular Endothelial Growth Factor (VEGF) by DNA Shuffling,Journal of Immunotherapy, 2016, 39(7): 260-268.

(7) Zhang L, Gao Z, Zhao X, Qi G*, A natural lipopeptide of surfactin for oral delivery of insulin, Drug Delivery, 2016, 23(6):2084-93.

(8) Gan P, Jin D, Zhao X, Gao Z, Wang S, Du P, Qi G*, Bacillus-produced surfactin attenuates chronic inflammation in atherosclerotic lesions of ApoE(-/-) mice. International Immunopharmacology, 2016, 35:226-34.

(9) Gao H, Qi G, Yin R, Zhang H, Li C, Zhao X*, Bacillus cereus strain S2 shows high nematicidal activity against Meloidogyne incognita by producing sphingosine, Scientific Reports, 2016, 6: 28756.

(10) Wei X, Zhou Y, Chen J, Cai D, Wang D, Qi G, Chen S*, Efficient expression of nattokinase in Bacillus licheniformis: host strain construction and signal peptide optimization, Journal of Industrial Microbiological Biotechnology, 2015, 42:287-295.

(11) Gao Z, Zhao X, Yang T, Shang J, Shang L,Mai H, Qi G*, Immunomodulation therapy of diabetes by oral administration of a surfactin lipopeptide in NOD mice, Vaccine, 2014, 32: 6812-6819.

(12) Pan H, Zhao X, Gao Z, Qi G*, A surfactin lipopeptide adjuvanted hepatitis B vaccines elicit enhanced humoral and cellular immune responses in mice, Protein & Peptide Letters, 2014, 21(9): 901-10.

(13) Qi G, Kang Y, Li L, Xiao A, Zhang S, Wen Z, Xu D, Chen S*, Deletion of meso-2, 3-butanediol dehydrogenase gene budC for enhanced D-2, 3-butanediol production in Bacillus licheniformis, Biotechnology for Biofuels, 2014, 7: 16.

(14) Tian G, Fu J, Wei X, Ji Z, Ma X, Qi G and Chen S*, Enhanced expression of pgdS gene for high production of poly-γ-glutamic aicd with lower molecular weight in Bacillus licheniformis WX-02, Journal of Chemical Technology and Biotechnology, 2014, 89: 1825-1832.

(15) Gao Z, Zhao X, Lee S, Li J, Liao H, Zhou X, Wu J, Qi G*, WH1fungin a surfactin cyclic lipopeptide is a novel oral immunoadjuvant, Vaccine, 2013, 31:2796-2803.

(16) Qi G, Zhang X, Zhao X*, Endophytic Bacillus subtilis WH2 containing Pinellia ternata agglutinin showed insecticidal activity against whitebacked planthopper Sogatella furcifera, BioControl, 2013, 58:233-246.

(17) Li X, Long D, Ji J, Yang W, Zeng Z, Guo S, Ji Z, Qi G, Chen S*, Sample preparation for the metabolomics investigation of poly-gamma-glutamate -producing Bacillus licheniformis by GC-MS, Journal of Microbiological Methods, 2013, 94: 61-67.

(18) Gao Z, Wang S, Qi G, Pan H, Zhang L, Zhou X, Liu J, Zhao X*, Wu J*, A surfactin cyclopeptide of WH1fungin used as a novel adjuvant for intramuscular and subcutaneous immunization in mice, Peptides, 2012, 38(1): 163-71.

(19) Andrian E, Qi G, Wang J, Halperin SA, Lee SF*, Role of surface proteins SspA and SspB of Streptococcus gordonii in innate immunity, Microbiology, 2012, 158: 2099-106.

(20) Yao D, Ji Z, Wang C, Qi G, Zhang L, Ma X, Chen S*, Co-producing iturin A and poly-γ-glutamic acid from rapeseed meal under solid state fermentation by the newly isolated Bacillus subtilis strain 3-10, World Journal of Microbiological Biotechnology, 2012, 28:985-991.

(21) Yangtse W, Zhou Y, Lei Y, Qiu Y, Wei X, Ji Z, Qi G, Yong Y, Chen L, Chen S*, Genome sequence of Bacillus licheniformis WX-02, Journal of Bacteriology, 2012, 194(13): 3561-3562. 

(22) Li J, Zhao X, Zhang S, Wang S, Du P, Qi G*, ApoB-100 and HSP60 peptides exert a synergetic role in inhibiting early atherosclerosis in immunized ApoE-null mice, Protein & Peptide Letters, 2011, 18(7):733-40.

(23) Qi G, Li J, Wang S, Xin S, Du P, Zhang Q, Zhao X*, A chimeric peptide of intestinal trefoil factor containing cholesteryl ester transfer protein B cell epitope significantly inhibits atherosclerosis in rabbits after oral administration, Peptides, 2011, 32 (4): 790-796. 

(24) Qi G, Lu J, Zhang P, Li J, Zhu F, Chen J, Liu Y, Yu Z, Zhao X*, The cry1Ac gene of Bacillus thuringiensis ZQ-89 encodes a toxin against long-horned beetle adult, Journal of Applied Microbiology, 2011, 110 (5): 1224-1234. 

(25) Qi G, Lan N, Ma X, Yu Z, Zhao X*, Controlling Myzus persicae with recombinant endophytic fungi Chaetomium globosum expressing Pinellia ternata agglutinin, Journal of Applied Microbiology, 2011, 110 (5): 1314-1322.

(26) Qi G, Zhu F, Du P, Yang X, Qiu D, Yu Z, Chen J, Zhao X*, Lipopeptide induces apoptosis in fungal cells by a mitochondria-dependent pathway, Peptides, 2010, 31 (11): 1978-1986. 

(27) Qi G, Mao S, Zhu F, Yu Z, Zhao X*, In vitro assessment of plant lectins with anti-pinwood nematode activity, Journal of Invertebrate Pathology, 2008, 98 (1): 40-45. 

(28) Mao D, Gu K, Qi G, Zhu Z, Li Z, Wu J, Liu J*, Cao R*, DNA vaccination with a plasmid encoding CETP epitope fused with hepatitis B virus core protein and containing CpG DNA inhibits atherosclerosis in a rabbit model, Vaccine, 2006, 24: 4942-4950.

(29) Qi G, Long J, Zhao X, Liu W, Wu J, Liu J*, Antibody against cholesteryl ester transfer protein (CETP) elicited by a recombinant chimeric enzyme vaccine attenuated atherosclerosis in a rabbit model, Life Sciences, 2005, 77: 2690-2702.

(30) Qi G, Long J, Yang X, Liu W, Wu J, Zhao X, Liu J*, Vaccinating rabbits with a cholesteryl ester transfer protein (CETP) B cell epitope carried by heat shock protein-65 (HSP65) for inducing anti-CETP antibodies and reducing aortic lesions in vivo, Journal of Cardiovascular Pharmacology, 2005, 45: 591-598.

(31) Qi G, Lin J, Cao R, Yang X, Mao D, Wu J, Shen X, Xu Q, Roque RS, Zhao X, Liu J*, Asparaginase display of polypeptides in the periplasm of Escherichia coli: potential rapid pepscan technique for antigen epitope mapping, Journal of Immunological Methods, 2005, 299: 9-19.

(32) Qi G, Mao D, Wu J, Liao Z, Li Z, Roque RS, Liu J*, Long-lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65 kDa in the absence of adjuvants, Vaccine, 2004, 22: 3187-3194.

(33) Qi G, Wu J, Yang X, Roque RS, Liu J*, Expressing and purifying an anti-atherosclerosis polypeptide vaccine in Escherichia coli, Protein Expression and Purification, 2004, 36:198-206. 2004.

授权专利

祁高富,赵秀云,朱发银,文凯,张世超,喻子牛,一株产促真菌凋亡脂肽的解淀粉芽胞杆菌及由该菌制备的脂肽与应用,2008.10.27,中国,ZL200810197403.4

其他成果

 

获得奖励

 

主讲课程

生物药物学、免疫学、免疫学实验、生物技术药物(研究生)

 

研究生招生专业

微生物代谢

微生物药物

应用微生物

 

联系方式

电话:15387157411

电子邮箱:qigaofu@mail.hzau.edu.cn

办公地点:微生物农药国家工程研究中心

 

实验室介绍及网址:

中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 Fax:+86-27-87282469
CopyRight©2001-2010 华中农业大学生命科学技术学院 版权所有; E-mail:bio@mail.hzau.edu.cn 技术支持:现代教育技术中心