生物化学教研室Brief Introduction

陈小冬
时间:2015-11-03

 

陈小冬 副教授 硕导

教育经历

1994-1998  湖南农业大学 淡水渔业 本科

1998-2004  华中农业大学 生化与分子生物学 硕博连读

2003-2004  德国,做博士论文

 

科研与学术工作经历

2014.11至今华中农业大学生命科学技术学院历任副教授

2013.11至2014.11美国康奈尔大学农业与生命科学学院访学

2007.1至2013.11 华中农业大学生命科学技术学院历任副教授

2004.7至2006.12 华中农业大学生命科学技术学院历任讲师

 

研究方向

动物脂肪代谢及其相关疾病的分子机理

 

代表性论文

1. Zheng HL, Dong XK, Liu NXia WM, Zhou LL, Chen XJ, Yang ZQ, Chen XD*. Regulation and mechanism of mouse miR-130a/b in metabolism-related inflammation. Int J Biochem Cell Biol. 2016; 74: 72-83.

2. Wang SB, Lei T, Zhou LL, Zeng CP, Zheng HL, Liu N, Yang ZQ, Chen XD*. Functional analysis and transcriptional regulation of porcine six transmembrane epithelial antigen of prostate 4 (STEAP4) gene and its novel variant in hepatocytes. Int J Biochem Cell Biol. 2013; 45(3): 612-620. 

3. Zhang Y, Lei T, Huang JF, Wang SB, Zhou LL, Yang ZQ, Chen XD*. The link between fibroblast growth factor 21 and sterol regulatory element binding protein 1c during lipogenesis in hepatocytes. Molecular and Cellular Endocrinology 2011; 342(1-2): 41-47.

4. Lei T, Bi Y, Gao MJ, Gao SM, Zhou LL, Zheng HL, Chen XD*. HES1 inhibits adipogenesis of porcine mesenchymal stem cells via transcriptional repression of FAD24. Domest Anim Endocrinol. 2013; 45(1): 28-32. 

5. Chen XD, Chen YL, Wang SB, Lei T, Gan L, Yang ZQ*. Molecular Characterization and functional analysis of porcine macrophage migration inhibitory factor (MIF) gene. Cytokine. 2010; 50(1): 84-90. 

6. Chen XD, Lei T, Xia T, Gan L, Yang ZQ. Increased expression of resistin and tumour necrosis factor-alpha in pig adipose tissue as well as effect of feeding treatment on resistin and cAMP pathway. Diabetes Obes Metab. 2004; 6: 271-279.

7. Feng SQ, Chen XD, Xia T, Gan L, Dai MH, Qiu H, Peng Y, Lei T, Yang ZQ. Cloning, chromosome mapping and expression pattern of pig angptl3 and angptl4. Cytogenetic and Genome Research. 2006; 114: 44-49. 

8. Zhang J, Lei T, Chen XD, Peng Y, Long H, Zhou L, Huang J, Chen ZL, Long QQ, Yang ZQ. Resistin Up-Regulates COX-2 Expression via TAK1-IKK-NF-kappaB Signaling Pathway. Inflammation 2010; 33: 25-33. 

9. Chen ZL, Lei T, Chen XD, Zhang J, Yu A, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Porcine KLF gene family: Structure, mapping, and phylogenetic analysis. Genomics 2010; 95: 111-119. 

10. Qiu H, Xia T, Chen XD, Zhao XL, Gan L, Feng SQ, Lei T, Yang ZQ. Cloning, comparative characterization of porcine SCAP gene, and identification of its two splice variants. Mol Genet Genomics. 2006; 276: 187-196.

11. Dai MH, Xia T, Chen XD, Gan L, Feng SQ, Qiu H, Peng Y, Yang ZQ. Cloning and characterization of porcine resistin gene. Domest Anim Endocrinol. 2006; 30(2):88-97.

12. Qiu H, Xia T, Chen XD, Gan L, Feng SQ, Lei T, Dai MH, Yang ZQ. Characterization of pig INSIG1 and assignment to SSC18. Anim Genet. 2005; 36(3):284-6.

13. Qiu H, Xia T, Chen XD, Feng SQ, Gan L, Lei T, Peng Y, Zhang GD, Nie T, Yue GP, Zhao XL, Yang ZQ. Sequencing and chromosome mapping of pig INSIG 2 and a related pseudogene. Anim Genet. 2005; 36(2):188-9. 

14. Peng Y, Lei T, Yuan JH, Chen XD, Long QQ, Zhan J, Lei P, Feng B, Yang ZQ. Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009; 36(3): 491-7.

15. Li YH, Lei T, Chen XD, Xia T, Peng Y, Long QQ, Zhang J, Feng SQ, Zhou L, Yang ZQ. Molecular cloning, chromosomal location and expression pattern of porcine CIDEa and CIDEc. Molecular Biology Reports 2009; 36:575-82.

16. Jin D, Tan HJ, Lei T, Gan L, Chen XD, Long QQ, Feng B, Yang ZQ. Molecular cloning and characterization of porcine sirtuin genes. Comparative Biochemistry and Physiology, Part B 2009; 149: 348-358.

17. Cheng M, Yang H, Long H, Chen X, Yang Z, Lei T. Molecular characterization and transcriptional analysis of fad24 in pigs. Gene 2012; 503(2): 208-14.

18. Huang JF, Zhang J, Lei T, Chen XD, Zhang Y, Zhou L, Yu A, Chen ZL, Zhou R, Yang ZQ. Cloning of porcine chemerin, ChemR23 and GPR1 and their involvement in regulation of lipogenesis. BMB reports 2010; 43(7): 491-498.

19. Zhou L, Xia T, Li Y, Chen XD, Peng Y, Yang ZQ. Transcriptional regulation of the resistin gene. Domest Anim Endocrinol. 2006; 30: 98-107.

20. Yin CJ, Long QQ, Lei T, Chen XD, Long H, Peng B, Peng Y, Yang ZQ. Lipid accumulation mediated by adiponectin in C2C12 myogenesis. BMB Rep. 2009; 42:667-72.

21. Dai MH, Xia T, Zhang GD, Chen XD, Gan L, Feng SQ, Qiu H, Peng Y, Yang ZQ. Cloning, expression and chromosome localization of porcine adiponectin and adiponectin receptors genes. Domest Anim Endocrinol. 2006; 30: 117-25.

22. Zhang R, Lei T, Qi YM, Lei P, Chen ZL, Chen XD, Yang ZQ. Molecular cloning, chromosomal localization and expression pattern of porcine ADP-ribosylation factor(Arf) gene family. Animal science journal 2010; 81(4): 425-431.

23. Nie T, Zhao XL, Qiu H, Xia T, Chen XD, Gan L, Feng SQ, Lei T, Dai MH, Yang ZQ. Sequencing analysis and map assignment of pig SREBF2 and ADFP gene. Anim Genet. 2005; 36:455-457.

24. Lei T, Yang ZQ, Xia T, Gan L, Chen XD, Yuan JH and Zhu Y. Stage-specific Expression of Leukaemia Inhibitory Factor and its Receptor in Rabbit Pre-implantation Embryo and Uterine Epithelium During Early Pregnancy.  Reproduction in Domestic Animals 2004; 39: 13–18. 

25. Li XF, Lei T, Xia T, Chen XD, Feng SQ, Chen HP, Chen ZL, Peng Y, Yang ZQ. Molecular characterization, chromosomal and expression patterns of three aquaglyceroporins (AQP3, 7, 9) from pig. Comparative biochemistry and physiology B-Biochemistry &Molecular Biology 2008; 149: 468-476.

26. Qi Y.M, Lei T, Zhou L, Chen XD, Long QQ, Long H, Jin D, Gan L, Yang ZQ. Genomic organization, alternative splicing and tissues expression of porcine CREB3L4 gene. Molecular biology reports 2009; 36: 1881-1888.

27. Chen H, Yao W, Jin D, Xia T, Chen X, Lei T, Zhou L, Yang Z. Cloning, Expression Pattern, Chromosomal Localization, and Evolution Analysis of Porcine Gnaq, Gna11, and Gna14. Biochemical Genetics 2008; 46: 398-405.

28. Qi YM, Lei T, Zhou L, Chen XD, Long H, Long QQ, Zhang RR, Yang ZQ, Gan L. Cloning, characterization, chromosomal mapping and tissue transcription analysis of porcine CREB2 and CREB3 genes. Folia Biol (Praha) 2009; 55: 137-144.

29. Xia T, Yuan JH, Gan Li, Feng B, Zhu Y, Chen XD, Zhang Peichao, Yang ZQ. Cloning, chromosome mapping and expression pattern of porcine PLIN and M6PRBP1 genes. Genetics Selection Evolution. 2008; 40(2):215-226.

30. Chen ZL, Gao X, Lei T, Chen XD, Zhou L, Yu A, Lei P, Zhang R, Long H, Yang ZQ. Molecular characterization, expression and chromosome localization of porcine PNPLA3 and PNPLA4. Biotechnol Lett. 2011;33(7):1327-37.

31. Chen HP, Xia T, Zhou L, Chen XD, Gan L, Yao WS, Peng Y, Yang ZQ. Gene organization, alternate splicing and expression pattern of porcine visfatin gene. Domest Anim Endocrinol. 2006; 32: 235-245. 

32. Zhou L, Li Y, Xia T, Feng SQ, Chen XD, Yang ZQ. Resistin overexpression impaired glucose tolerance in hepatocytes. Eur Cytokine Netw. 2006;17:189-195. 

33. Long QQ, Lei T, Feng B, Yin CJ, Jin D, Wu YL, Zhu XY, Chen XD, Gan L, Yang ZQ. Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Endocrinology. 2010; 151(7): 3195-203.

34. Yue GP, Du LR, Xia T, He XH, Qiu H, Xu LH, Chen XD, Feng SQ, Yang ZQ. One in vitro model for visceral adipose-derived fibroblasts in chronic inflammation. Biochem Biophys Res Commun. 2005; 333: 850-857.

35. Lei T, Xia T, Gan L, Chen XD, Yuan JH,Zhu YYang ZQ. Stage-specific Expression of Leukaemia Inhibitory Factor and its Receptor in Rabbit Pre-implantation Embryo and Uterine Epithelium During Early Pregnancy. Reproduction in Domestic Animals 2004; 39: 13–18. 

36.Yu XL, Jin D, Yu A, Sun J, Chen XD, Yang ZQ. p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes. Gene 2016; 589: 12–19.

 

获得奖励

 

主讲课程

 

研究生招生专业

 

联系方式

 

实验室介绍及网址

中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 Fax:+86-27-87282469
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