Structural insights into the photoactivation of Arabidopsis cryptochrome 2

Author：Ling Ma, Zeyuan Guan, Qiang Wang, Xuhui Yan, Jing Wang, Zhizheng Wang, Jianbo Cao, Delin Zhang, Xin Gong, Ping Yin

Nat Plants. 2020 Dec. 6(12). 1432-1438

Abstract：The blue-light receptor cryptochrome (CRY) in plants undergoes oligomerization to transduce blue-light signals after irradiation, but the corresponding molecular mechanism remains poorly understood. Here, we report the cryogenic electron microscopy structure of a blue-light-activated CRY2 tetramer at a resolution of 3.1 Å, which shows how the CRY2 tetramer assembles. Our study provides insights into blue-light-mediated activation of CRY2 and a theoretical basis for developing regulators of CRYs for optogenetic manipulation.

 DOI: 10.1038/s41477-020-00800-1