Cinque Terre


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陈振夏 博士 教授 博士生导师

Zhen-Xia Chen, Ph.D., Professor, PhD Supervisor


Address: Gene Building 418, No.1 Shizishan Street Hongshan District, Wuhan, Hubei Province 430070

手机(Cell: 86-180 8611 3785

E-mail: zhen-xia.chen AT





Sex dimorphism in phenotype is mainly caused by genes differentially expressed between sexes (called sex-biased genes). Many sex-biased genes are genes that encode long noncoding RNAs (lncRNA). Although some sex-biased lncRNAs have been found to regulate gonad development, the function of most lncRNAs are still unknown. Our previous study validated the transcriptome annotation of noncoding functional elements, and suggested the contribution of sex-related drives in the evolution of noncoding sequences in animal genomes. Although some sex-biased lncRNAs were found to be involved in sex development, the function of most sex-biased lncRNAs were still unknown. We thus focus on sex-biased lncRNAs, systematically identifying sex-biased lncRNAs in multiple animal species (including fruitfly, zebrafish, medaka, chicken, human, and etc.) with high-throughput sequencing techniques, and exploring their evolutionary mechanisms, functions in sex development, and potential effects on diseases. The implementation of our study will provide a solid foundation for revealing the function of sex-biased lncRNAs, and be important for precision medicine.

We sincerely welcome the participation of undergraduates, postgraduates, doctoral students, postdoctoral fellows and other scientific researchers who love science and are good at learning and cooperating.


2006-2011 北京大学 生命科学技术学院生物信息中心 理学博士学位

Ph.D, Bioinformatics, Center for Bioinformatics, College of Life Sciences, Peking University, Beijing, China. Dissertation: Deficiency of X-linked inverted duplicates in Drosophila melanogaster and the underlying mechanisms. Mentor: Dr. Manyuan Long. 2006 - 2011

2002-2006 华中农业大学 生命科学技术学院 国家生命科学与技术人才培养基地 理学学士学位

Bachelor of Science, Biotechnology, National life science and technology talents training base, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China. 2002 - 2006

2003-2006 武汉大学 新闻传播学院学院 新闻学 文学学士学位

Bachelor of Arts, Journalism, School of Journalism and Communication, Wuhan University, Wuhan, Hubei, China. 2003 - 2006


20016-至今 华中农业大学生命科学技术学院 教授

Professor, College of Life Sciences & Technology, Huazhong Agricultural University, Wuhan, China. 2016.9-Present

2011-2016 美国国立卫生研究院 消化、糖尿病、肾脏病研究所 博士后

Postdoc, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States. Mentor: Dr. Brian Oliver. 2011.9 - 2016.9



Bioinformatics (


Introduction to Life sciences (



Third prize, National University Micro Lesson Teaching Competition (Life sciences), 2017.


Second prize, Young Teachers’ Teaching Competition, College of Life Science and Technology, Huazhong Agricultural University, 2017.


Distinguished Scientist Award, 2016 NIHCSSA Annual Symposium, Bethesda, Maryland, 2016.


Women Scientists Travel Awards, The 10th International Conference on Genomics, Shenzhen, Guangzhou, China, 2015.


Excellent Doctoral Dissertation, Peking University, Beijing, China, 2011.


Outstanding Graduate, Peking University, Beijing, China, 2011.


2nd Place. University Students’ Outstanding Achievements in Scientific Research, Hubei Province, China, 2006.



Research Reports on Genomic Evolution and Computational Biology

Luo ZH, Shi MW, Yang Z, Zhang HY*, Chen ZX*. pyMeSHSim: an integrative python package to realize biomedical named entity recognition, normalization and comparison (Submitted).

Shi MW#, Zhang NA#, Shi CP, Liu CJ, Luo ZH, Wang DY, Guo AY*, Chen ZX*. SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes. Nucleic Acids Research. 2019.

Chen ZX*, Oliver B, Zhang YE, Gao G, Long M*. Expressed Structurally-stable Inverted Duplicates in Mammalian Genomes as Functional Noncoding Elements. Genome Biology and Evolution. 9(4):981–992 (2017).

Lin Y, Chen ZX, Oliver B, Harbison ST*. Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster. G3-Genes Genomes Genetics. 6: 4197-4210 (2016).

Lin Y, Golovnina K, Chen ZX, Lee HN, Negron YL, Sultana H, Oliver B, Harbison ST*. Comparison of normalization and differential expression analyses using RNA-Seq data from 726 individual Drosophila melanogaster. BMC Genomics 17: 28 (2016).

Chen ZX & Oliver B*. X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads. G3-Genes Genomes Genetics. 5(6):1057-63 (2015).

Clough E, Jimenez E, Kim YA, Whitworth C*, Neville MC, Hempel L, Pavlou H, Chen ZX, Sturgill D, Dale R, Smith HE, Przytycka TM*, Goodwin SF*, Doren MV*, Oliver B*. Sex- and Tissue-specific Functions of Drosophila Doublesex Transcription Factor Target Genes.  Dev. Cell. 31(6):761-73 (2014).

Chen ZX#, Sturgill D#, Qu J, Jiang H, Park S, Boley N, Suzuki AM, Fletcher AR, Plachetzki DC, FitzGerald PC, Artieri CG, Atallah J, Barmina O, Brown JB, Blankenburg KP, Clough E, Dasgupta A, Gubbala S, Han Y, Jayaseelan JC, Kalra D, Kim YA, Kovar CL, Lee SL, Li M, Malley JD, Malone JH, Mathew T, Mattiuzzo NR, Munidasa M, Muzny DM, Ongeri F, Perales L, Przytycka TM, Pu LL, Robinson G, Thornton RL, Saada N, Scherer SE, Smith HE, Vinson C, Warner CB, Worley KC, Wu YQ, Zou X, Cherbas P, Kellis M, Eisen MB, Piano F, Kionte K, Fitch DH, Sternberg PW, Cutter AD, Duff MO, Hoskins RA, Graveley BR, Gibbs RA, Bickel PJ, Kopp A, Carninci P, Celniker SE, Oliver B*, Richards S. Comparative analysis of the D.melanogaster modENCODE transcriptome annotation. Genome Research. 24:1209-23 (2014).

Chen ZX*, Golovnina K, Sultana H, Kumar S, Oliver B. Transcriptional effects of gene dose reduction. Biology of Sex Differences, 5(1): 5 (2014).

Chen ZX, Zhang YE, Vibranovski M, Luo J, Gao G*, Long M*. Deficiency of X-linked inverted duplicates with male-biased expression and the underlying evolutionary mechanisms in the Drosophila genome. Mol Biol Evol. 28:2823-2832 (2011).



Golovnina K, Chen ZX, Lin Y, Sultana H, Oliver B, Harbison S, 2015. mRNA-Seq data of whole female/male individuals from 16 inbred Drosophila melanogaster DGRP lines. Gene Expression Omnibus GSE60314.

Chen ZX, Oliver B. 2015. mRNA-Seq of female, male, and sex-transformed Drosophila melanogaster heads from flies heterozygous for deletions on chromosome X and 3L. Gene Expression Omnibus GSE60571.

Chen ZX, Oliver B. 2015. CAGE-Seq of gonads and carcasses from D. melanogaster and D. pseudoobscura. Gene Expression Omnibus GSE66284.

Sturgill D, Chen ZX, Kopp A, Richards S, Oliver B. 2013. mRNA-Seq of whole adult females and males, and mixed sex embryos, from multiple Drosophila species. Gene Expression Omnibus GSE43321.

Oliver B, Chen ZX, Sturgill. 2013. New Drosophila pseudoobscura RNA-Seq coverage data. FlyBase.


Research Report on Social sciences

龙漫远,陈振夏. 达尔文和他改变的世界.科学文化评论. 6(4): 13-26 (2009).

陈振夏. 大学生课外活动参与状况调查与研究.华中农业大学学报(社科版), 5,6: 118-121 (2005).


Other Publications

陈振夏. 果蝇的祖先天生双性恋?牛顿科学世界, (2010)

陈振夏. Y染色体少了,男人要没了?南都周刊, (2009)

陈振夏. 兴趣不是奢侈品. ——从喜欢花鸟虫鱼的日本皇子说起.科学时报, (2008).

Chen ZX. Genomics: A promising investment opportunity. BiotechBlog (2014).

陈振夏. 《在燕园留下的第一次》. 霍晓丹 编著. 《绚彩燕园青春北大——60位北大优秀毕业生的校园记忆》,北京大学出版社(2011).

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