Cinque Terre

吴淑可

来源: 责任编辑:熊晖 发布:2021-01-27 点击量:




吴淑可 博士 特聘教授 博士生导师


教育经历

2006-2010 北京大学 生物技术 理学学士

2010-2015 新加坡国立大学 化学工程与制药工程 理学博士


科研与工作经历

2015-2017 新加坡国立大学 合成生物学项目 博士后

2017-2018 瑞士巴塞尔大学 化学系 博士后

2018-2020 德国格赖夫斯瓦尔德大学 生化系 洪堡学者

2020-至今 华中农业大学 生命科学技术学院 特聘教授


研究方向简介

1. 工业生物技术与绿色生物制造、酶工程与生物催化、合成生物学。重点关注可用于农业系统中的酶和微生物,农用化学品和植物天然产物的发现和生物制造。

2. 从微生物中发现新酶催化反应/代谢途径等,并充分开发其新反应用于生物合成。


研究生招生/博士后招聘

招收硕士生(3-4/年)博士(1-2/年):生物工程、微生物学、生物与医药

招收博士后2-3名:相关专业特别是酶工程、酵母代谢工程、植物天然产物生物合成,税前年薪有22-30万,并有子女入学、入住博士后公寓等支持,非常欢迎来信咨询。


代表性研究成果

1. Shuke Wu, Radka Snajdrova, Jeffrey C. Moore, Kai Baldenius,* Uwe T. Bornscheuer*. Biocatalysis: Enzymatic Synthesis for Industrial Applications. Angewandte Chemie International Edition 2021, 60 (1), 88-119. [IF 12.959] DOI: 10.1002/anie.202006648

2. Shuke Wu,* Yi Zhou, Daniel Gerngross, Markus Jeschek, Thomas R. Ward*. Chemo-enzymatic Cascades to Produce Cycloalkenes from Bio-based Resources. Nature Communications 2019, 10, 5060. [IF 12.121] DOI: 10.1038/s41467-019-13071-y

3. Shuke Wu,# Yi Zhou,# Johannes G. Rebelein,# Miriam Kuhn, Hendrik Mallin, Jingming Zhao, Nico V. Igareta, Thomas R. Ward*. Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes. Journal of the American Chemical Society 2019, 141, 15869-15878. [IF 14.612] DOI: 10.1021/jacs.9b06923

4. Shuke Wu, Yi Zhou, Zhi Li*. Biocatalytic Selective Functionalisation of Alkenes via Single-step and One-pot Multi-step Reactions. Chemical Communications 2019, 55, 883-896. [IF 5.996] DOI: 10.1039/C8CC07828A

5. Shuke Wu, Zhi Li*. Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis. ChemCatChem 2018, 10, 2164-2178. [IF 4.853] DOI: 10.1002/cctc.201701669

6. Shuke Wu, Ji Liu, Zhi Li*. Biocatalytic Formal Anti-Markovnikov Hydroamination and Hydration of Aryl Alkenes. ACS Catalysis 2017, 7, 5225-5233. [IF 12.350] DOI: 10.1021/acscatal.7b01464

7. Shuke Wu, Yi Zhou, Daniel Seet, Zhi Li*. Regio- and Stereoselective Oxidation of Styrene Derivatives to Arylalkanoic Acids via One-Pot Cascade Biotransformations. Advanced Synthesis & Catalysis 2017, 359, 2132-2141. [IF 5.851] DOI: 10.1002/adsc.201700416

8. Shuke Wu, Ji Liu, Zhi Li*. Organic Synthesis via Oxidative Cascade Biocatalysis. Synlett 2016, 27, 2644-2658. [IF 2.006] DOI: 10.1055/s-0036-1588627

9. Yi Zhou,# Shuke Wu,# Zhi Li*. Cascade Biocatalysis for Sustainable Asymmetric Synthesis: from Biobased ʟ-Phenylalanine to High-value Chiral Chemicals. Angewandte Chemie International Edition 2016, 55, 11647-11650. [IF 12.959] DOI: 10.1002/anie.201606235

10. Shuke Wu, Yi Zhou, Tianwen Wang, Heng-Phon Too, Daniel I. C. Wang, Zhi Li*. Highly Regio- and Enantioselective Multiple Oxy- and Amino-functionalizations of Alkenes by Modular Cascade Biocatalysis. Nature Communications 2016, 7, 11917. [IF 12.121] DOI: 10.1038/ncomms11917

11. Shuke Wu, Yongzheng Chen, Yi Xu, Aitao Li, Qisong Xu, Anton Glieder, Zhi Li*. Enantioselective trans-Dihydroxylation of Aryl Olefins by Cascade Biocatalysis with Recombinant Escherichia coli Coexpressing Monooxygenase and Epoxide Hydrolase. ACS Catalysis 2014, 4, 409-420. [IF 12.350] DOI: 10.1021/cs400992z

12. Shuke Wu, Aitao Li, Yit Siang Chin, Zhi Li*. Enantioselective Hydrolysis of Racemic and Meso-epoxides with Recombinant Escherichia coli Expressing Epoxide Hydrolase from Sphingomonas sp. HXN-200: Preparation of Epoxides and Vicinal Diols in High ee and High Concentration. ACS Catalysis 2013, 3, 752-759. [IF 12.350] DOI: 10.1021/cs300804v


授权专利

1. Zhi Li, Shuke Wu, Yi Zhou, Benedict Ryan Lukito. “Bioproduction of Phenethyl Alcohol, Aldehyde, Acid, Amine, and Related Compounds.” WO2018217168.

2. Zhi Li, Shuke Wu. “Production of Chiral 1,2-Amino Alcohols and α-Amino Acids from Alkenes by Cascade Biocatalysis.” US20170067084.

3. Zhi Li, Shuke Wu. “Production of Enantiopure α-Hydroxy Carboxylic Acids from Alkenes by Cascade Biocatalysis.” WO2014189469.

学术服务

担任期刊客座编辑: Bioresources and Bioprocessing, Frontiers in Catalysis.

担任期刊审稿人: ACS Synthetic Biology, ACS Chemical Biology, ACS Sustainable Chemistry & Engineering, Biochemical Engineering Journal, Chemical Engineering Science, Bioresources and Bioprocessing, Enzyme and Microbial Technology, Marine Biotechnology, Catalysis Letters, Bioprocess and Biosystems Engineering, Applied Biochemistry and Biotechnology, Heliyon.

获得奖励

德国洪堡学者奖学金Alexander von Humboldt Fellowship for Postdoctoral Researchers (2018-2020)

欧盟玛丽居里行动计划卓越奖Seal of Excellence in Marie Skłodowska-Curie Actions (H2020-MSCA-IF-2017)

瑞士政府优秀奖学金(博士后)Swiss Government Excellence Scholarship (2017-2018, postdoc study)

新加坡-麻省理工联盟奖学金(博士)Singapore-MIT Alliance Fellowship (2010–2014, PhD study)

主讲课程

合成生物学


联系方式

电子邮箱:shukewu(at)mail.hzau.edu.cn

办公地点:第一综合楼A507

个人网页:https://www.researchgate.net/profile/Shuke_Wu



中国·湖北·武汉 南湖狮子山街一号430070 Tel:+86-27-87282101 E-mail:bio@mail.hzau.edu.cn

CopyRight©2001-2010华中农业大学生命科学技术学院 版权所有 技术支持:信息技术中心