教授Brief Introduction

教授
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韩文元
时间:2018-12-04

教育经历

20049月至20087月:山东大学 本科学士学位 生态学专业

20089月至20117月:山东大学 硕士学位 微生物学专业

20119月至20155月:丹麦哥本哈根大学 博士学位 生物学专业

 

工作经历:

20158月至20177月:丹麦哥本哈根大学 博士后

20178月至20181月:丹麦哥本哈根大学 助理教授

20189月至今:华中农业大学生命科学技术学院,教授

 

研究方向:

1.      微生物与病毒的相互作用

2.      CRISPR系统的核酸干扰机制及其抑制病毒入侵的功能

3.      CRISPR相关技术的探索

 

欢迎具有生物化学,细胞生物学,微生物学,分子生物学背景的本科生、研究生加盟本课题组学习或继续深造。同时,本实验室招聘科研助理,博士后若干名。有意者请将个人简历发送邮件至hanwenyuan@mail.hzau.edu.cn

 

代表性成果

1. Wenyuan Han, Stefano Stella, Yan Zhang, Tong Guo, Karolina Sulek, Li Peng-Lundgren, Guillermo Montoya, Qunxin She* . A Type III-B Cmr effector complex catalyzes the synthesis of cyclic oligoadenylate second messengers by cooperative substrate binding. Nucleic Acids Res. 2018 Nov 2;46(19):10319-10330.

2. Tong Guo, Wenyuan Han*, Qunxin She*. Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus. RNA Biol. 2018 Jul 9:1-8.

3. Wenyuan Han, Saifu Pan, Blanca Lopez-Mendez, Guillermo Montoya and Qunxin She*. Allosteric regulation of Csx1, a type IIIB-associated CARF domain ribonuclease by RNAs carrying a tetraadenylate tail. Nucleic Acids Res. 2017 Oct 13;45(18):10740-10750.

4. Wenyuan Han, Yingjun Li, Ling Deng, Mingxia Feng, Wenfang Peng, S➢ren Hallstr➢m, Jing Zhang, Nan Peng, Yun Xiang Liang, Malcolm F. White and Qunxin She*. A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction. Nucleic Acids Res. 2017 Feb 28;45(4):1983-1993.

5. Wenyuan Han, Yanqun Xu, Xu Feng, Yun Xiang Liang, Li Huang, Yulong Shen and Qunxin She*. NQO-induced DNA-less cell formation is associated with chromatin protein degradation and dependent on A0A1-ATPase in Sulfolobus. Front Microbiol. 2017 Aug 14;8:1480.

6. Wenyuan Han*, Xu Feng and Qunxin She*. Reverse gyrase functions in genome integrity maintenance by protecting DNA breaks in vivo. Int. J. Mol. Sci. 2017 Jun 22;18(7).

7. Wenyuan Han, Yulong Shen* and Qunxin She*. Nanobiomotors of archaeal DNA repair machineries: current research status and application potential. Cell Biosci. 2014 Jun 25;4:32.

8. Wenyuan Han and Qunxin She*. CRISPR history: discovery, characterization, application and prosperity. Prog Mol Biol Transl Sci. 2017;152:1-21.

9. Pengjuan Liang, Wenyuan Han, Qihong Huang, Yanze Li, Jinfeng Ni, Qunxin She and Yulong Shen*. Knockouts of RecA-like proteins RadC1 and RadC2 have distinct responses to DNA damage agents in Sulfolobus islandicus. J Genet Genomics. 2013 Oct 20;40(10):533-42.

10. Valeria Visone, Wenyuan Han, Giuseppe Perugino, Giovanni del Monaco, Qunxin She, Mosè Rossi, Anna Valenti , Maria Ciaramella*. In vivo and in vitro protein imaging in thermophilic archaea by exploiting a novel protein tag. PLoS One. 2017 Oct 3;12(10):e0185791.

11. Mengmeng Sun, Xu Feng, Zhenzhen Liu, Wenyuan Han, Yun Xiang Liang and Qunxin She. An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea. Nucleic Acids Res. 2018 Jul 27;46(13):6697-6711.

12. Xu Feng, Mengmeng Sun, Wenyuan Han, Yun Xiang Liang and Qunxin She. A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea. Nucleic Acids Res. 2018 Aug 21;46(14):7085-7096.

13. Yingjun Li, Yan Zhang, Jinzhong Lin, Saifu Pan, Wenyuan Han, Nan Peng, Yun Xiang Liang and Qunxin She*. Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR-Cas system by binding to target RNA and crRNA. Nucleic Acids Res. 2017 Nov 2;45(19):11305-11314.

 

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